Process for the preparation of substitution products of pyridin



?atented Fa. 24, 1931 UNITEDSTATES PATENT OFFICE cum: BATH, or muesnonr, GERMANY PROCESS FOR THE PREPARATION OF SUBS TITUTION PRODUCTS 01 PYRIDIN No Drawing. Application filed June 23, 1925,Seria1 No. 39,150, and in Germany June 30, 1924.

The present invention relates to the preparation of valuable substitution products of pyridin. These new products are obtained by introducing iodine into the 5-position of 5 2-substituted pyridine compounds effect by the well known diazo'method. This can be effected, by causing the diazo solutions prepared from 2-substituted-5-aminopyridin by addition of alkali nitrite to their acid solution 19 in the well known manner, to react with for instance potassium iodide, and the like.

By starting, for example, from 2-substitut ed-5-aminopyridin, which can be prepared comparatively easily, the reaction proceeds lfiquite smoothly. Products resulting therefrom contain the iodine in the B-position. In this way it is possible to get at compounds which show an exceedingly strong bactericidal effect.

Furthermore, I have found that I can prepare compounds of a particularly efficient nature and of great therapeutical value by having electro-negative substituents such as the hydroxy-group or the like, in the Q-position.

The following examples will illustrate my invention but I do not Wish to be limited to the compounds disclosed.

Example 1 Ewample' 2 whydrOXy-B-aminopvridin is diazotized by the usual method. On treating the diazo solution in the manner described above in Example 1 the whydroxy-B-iodopyridin is obtained, the sodium salt of which forms white crystals which are easily soluble in water.

The structural formula is IVhat I claim is y 1. Process for the preparation oi substitution products of pyridin which consists in diazotizing or substituted [3 amino pyridin and causing the diazo solution thus obtained to react with a metal iodide.

2. Process for the preparation of substitution products of pyridin which consists in diazotizing 0: hydroxy ,8 amino pyridin and causing the diazo solution thus obtained to react with a metal iodide.

3. Process for the preparation of substitution products of pyridin which consists in diazotizing u-l1ydroXy-B'-a1nino pyridin and causingthe diazo solution thus prepared to react with potassium iodide.

4t. As a composition of matter a-liydroxy- ,B-iodopyridin.

Signed at Berlin, in the country of Brandenburg and State of Prussia this 5th day of June, A. D. 1925,

De. CUR-T RXIITII. 

